The US Army Research Laboratory (ARL) is a nationally-recognized innovator of diagnostic biotechnologies and is currently focused on rapid characterization of potential biothreats.
The invented ARL system is comprised of a laser operating in the visible to near-infrared wavelength (approx. 650 to 1100 nanometers). The beam provides attractive and repulsive forces that can physically move and hold dielectric particles in a fashion akin to tweezers. This optical trap is proximal to a set up that enables analysis by SERS, where a generated surface-plasmon-resonance electric field yields a scattering spectrum unique to a subject particle. The spectrum is background-corrected and then compared with published data via an automated chemometric system.
The ARL invention is practiced using commercial-off-the shelf components and supplies. The system is non-invasive and non-destructive, does not suffer interference from water and is insensitive to the excitation wavelength. The patent includes a method of particle detection analysis and an approach for building a library of enhanced particle scattering spectra.
- Unique capability to characterize single particles with averaged linear dimension between 0.10 and 50 microns
- Reduces analysis time to minutes, instead of hours or days needed with traditional methods
- Commercial-off-the-shelf components apability to analyze single, dielectric particles with averaged linear dimension between 0.10 and 50 microns
- Broad applicability to military, medical, food preparation, homeland security, law enforcement
- Issued US Patent 7,515,269 available for license
- TRL 5 – Fully-developed detection system, with data available
- Potential for collaboration with US Army scientists and laboratory
Supplemental Technical Information:
- Development of Methodology Based on Commercialized SERS-Active Substrates for Rapid Discrimination of Poxviridae Virions
- Near-Infrared Surface-Enhanced-Raman-Scattering- Mediated Detection of Single Optically Trapped Bacterial Spores
For more information, contact:
Brian Metzger, PhD (406) 994-7782, firstname.lastname@example.org
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